Study of Zinc and Glycated Hb Levels in Diabetic Complications.

Abstract

Aim and Objective: Zinc has a significant role in various physiological metabolisms as it is an important cofactor for numerous enzymes. Alterations in serum concentrations of zinc in type 2 DM has been reported by several studies. We tried to evaluate the association of zinc and HbA1C in diabetic complications. Diabetes and its complications usually lead to increased production of free radicals which disturbs the internal milieu. Antioxidant enzymes like SOD are decreased due to low zinc concentrations resulting in tissue damage and various complications. Materials and Methods: In present study 50 type 2 DM persons diagnosed clinically with micro vascular complications like neuropathy and retinopathy are included as study group and 50 diabetic people without any complications as control group. Fasting blood samples were collected to analyse Zinc and HbA1C. HbA1C was estimated by HPLC method in D10 analyser. Zinc was analysed by colorimetric kit method. Results: There was significant decrease in serum concentrations of Zinc in study group when compared to control (50±12.5, 95 ± 20.42) (p≤ 0.001) HbA1C was significantly high in study group when compared to control (9.5.7±2.5.) (6.5±1.5) (p≤0.001). The correlation of HbA1C and zinc was done using Pearsons correlation coefficient and is inversely related ɤ = -0.4. Conclusion: In DM, HbA1C influences the profile of trace elements especially zinc and can be explained as one of the cause for delayed wound healing especially in patients with complications. Good glycemic control and zinc supplementation can prevent the complications.