Studies on Goitrogenic/ Antithyroidal Potentiality of Thiocyanate, Catechin and After Concomitant Exposure of Thiocyanate-Catechin

Abstract

In adequate iodine intake including and a number of environmental agents can affect thyroid gland functions in man and animals. Thiocyanate and catechin that arise for the consumption of cyanogenic and flavonoids containing foods respectively, affect thyroid hormone synthesis but the data comparing the goitrogenic/ antithyroid potentiality of thiocyanate and catechin when act individually or synergistically on thyroid function found scanty. Experimental animals were divided into groups and orally administered either thiocyanate or catechin or both in combination for 30 days followed by analysis of thyroid gland weight, histology, thyroid peroxidase, sodium potassium ATPase, 5’-deiodinase- I activities, thyroid hormone profiles, urinary iodine and urinary thiocyanate of each group of animals. Enlarged thyroid showing hypertrophic and hyperplastic changes, decreased thyroid peroxidase, sodium potassium ATPase, 5’-deiodinase- I activities activities and thyroid hormone profiles were observed in the treated groups. Overall results reveal that goitrogenic/ antithyroid potentiality found highest after concomitant exposure of thiocyanate and catechin followed by thiocyanate and least after catechin.