Effect of Jatropha curcas Latex on L3 Haemonchus contortus Larval Motility

Noorzaid Muhamad; SyahirahSazeli; Resni Mona; Jannathul Firdous

Noorzaid Muhamad Pre-clinical Department, Faculty of Medicine, Universiti Kuala Lumpur Royal College of Medicine Perak, No.3, Jalan Greentown, 30450, Ipoh, Perak, Malaysia.
SyahirahSazeli Pre-clinical Department, Faculty of Medicine, Universiti Kuala Lumpur Royal College of Medicine Perak, No.3, Jalan Greentown, 30450, Ipoh, Perak, Malaysia.
Resni Mona Pre-clinical Department, Faculty of Medicine, Universiti Kuala Lumpur Royal College of Medicine Perak, No.3, Jalan Greentown, 30450, Ipoh, Perak, Malaysia.
Jannathul Firdous Pre-clinical Department, Faculty of Medicine, Universiti Kuala Lumpur Royal College of Medicine Perak, No.3, Jalan Greentown, 30450, Ipoh, Perak, Malaysia.

Keywords: Anthelmintics, Jatropha curcas, Haemonchus contortus, Larval motility and Larvicidal effects.

Abstract

The anthelmintic resistance has limited the control of gastrointestinal nematodes of small ruminants and thus has awakened interest in the study of plants extract as a source of anthelmintics. These experiments were carried out to evaluate the in vitro efficacy of Jatrophacurcas latex extract against Haemonchuscontortus larval motility. To evaluate the larvicidal activity, H.contortus L3 were incubated with the extracts with varying concentration of 5 mg/mL, 10 mg/mL, 15 mg/mL and 20 mg/mL at 27°C for 48, 72 and 96 hrs. The results were subjected to the Kruskal-Wallis test (P less then 0.05). The extracts showed dose-dependent larvicidal effects. These results suggest that J.curcas can be used to control gastrointestinal nematodes of small ruminants.