Paclitaxel Loaded Magnetic Nanoparticles Induce In vivo Tumor Growth Inhibition in a Rat Glioblastoma Model

Phanithi Prakash Babu; Ramulu Chintala; Fahima Dilnawaz; Manas Panigrahi; Sanjeeb K Sahoo

Phanithi Prakash Babu Department of Biotechnology and Bioinformatics, School of Life Sciences, University of Hyderabad, Hyderabad-500046. India
Ramulu Chintala Department of Biotechnology and Bioinformatics, School of Life Sciences, University of Hyderabad, Hyderabad-500046. India
Fahima Dilnawaz Laboratory of Nano-medicine, Institute of Life Sciences, Bhubaneswar-751023. India
Manas Panigrahi Department of Neurosurgery, Krishna Institute of Medical Science, Secunderabad -500003. India
Sanjeeb K Sahoo Laboratory of Nano-medicine, Institute of Life Sciences, Bhubaneswar-751023. India

Keywords: Glioma, paclitaxel, Magnetic nano particles.

Abstract

Glioblastoma multiforme (GBM) is one of the most common and lethal diseases and the current therapeutic options remain sparse. The magnetic nanoparticles (MNPs) based drug delivery approach for the cancer treatment has become one of the promising options to achieve controlled drug delivery to target tumor. In the present study the efficacy of paclitaxel loaded glyceryl monooleate (PAC-GMO)-MNPs was evaluated by administering it in a glioblastoma induced rat model. The results of HandE and immunohistochemistry (IHC) suggest that the treatment with PAC-GMO-MNPs significantly reduced or inhibit the tumor growth as compared to the native drug and may be the potential vehicle for efficiently treating GBM.