Study of Anti-epileptic Drugs on Cognitive Parameters in Patients with Epilepsy

P R Anand Vijayakumar; M Pharm; Reima Elizabeth Jacob; Ritty Augustine; Rasmi Raj; Chennupati Rohith

P R Anand Vijayakumar Department of Pharmacy Practice, JSS College of Pharmacy, Udhagamandalam – 643 001. The Nilgiris, Tamilnadu, India
M Pharm Department of Pharmacy Practice, JSS College of Pharmacy, Udhagamandalam – 643 001. The Nilgiris, Tamilnadu, India
Reima Elizabeth Jacob Department of Pharmacy Practice, JSS College of Pharmacy, Udhagamandalam – 643 001. The Nilgiris, Tamilnadu, India
Ritty Augustine Department of Pharmacy Practice, JSS College of Pharmacy, Udhagamandalam – 643 001. The Nilgiris, Tamilnadu, India
Rasmi Raj Department of Pharmacy Practice, JSS College of Pharmacy, Udhagamandalam – 643 001. The Nilgiris, Tamilnadu, India
Chennupati Rohith Department of Pharmacy Practice, JSS College of Pharmacy, Udhagamandalam – 643 001. The Nilgiris, Tamilnadu, India

Keywords: Antiepileptic drug, epilepsy

Abstract

Background: In the management of epilepsy, classic Anti-Epileptic Drugs(AEDs) has been observed to produce a significant effect than classic AEDs on cognition. Purpose of the Study: To compare the prevalence of cognitive impairment in patients with epilepsy receiving newer and classical AEDs. Methods: This study is a cross-sectional observational study, with the intention of studying point prevalence of adverse cognitive effect of antiepileptic treatment.The MMSE scale was used to assess the cognitive function. The data obtained were analyzed using IBM SPSS Statistics 21 and Graph Pad Prism version 7.03. Result: It was found that patients on AEDs for more than 10 years and on poly-therapy were having the least MMSE scores implying more cognitive impairment. Among Various domains of MMSE assessed, it was found that orientation and language andvisuospatial skill were the significantly affected domains in patients receiving poly-therapy. Conclusion: Patients on poly-therapy with Classic AEDs had more cognitive impairment when compared to poly-therapy with Newer AEDs and combination of Classic AED and Newer AED.