Effect of Ethanolic Extract of Leaves of Boerhavia diffusa on Carbohydrate Metabolising Enzymes, Renal and Hepatic Markers in Streptozotocin Induced Diabetic Rats

Abstract

The present study was formulated to evaluate the effect of Boerhavia diffusa by using in vivo methods in normal and streptozotocin (STZ) induced diabetic rats. Diabetes mellitus was induced by single intraperitoneal injection of STZ (60 mg/kg body weight) in male Wistar rats. Various parameters such as carbohydrate metabolizing enzymes, renal and hepatic markers were studied in the normal and diabetes induced rat. The ethanolic extract of leaves of Boerhavia diffusa (ELBD) at a dose of 500 mg/kg body weight and glibenclamide, a standard oral hypoglycemic drug at a dose of 10 mg/kg body weight were administered orally to the diabetic induced groups for 45 days. The diabetic induced groups treated with the ELBD restored the elevated levels of renal and hepatic markers to normal levels. It also altered the activities of carbohydrate metabolizing enzymes to near normal. Thus, from the present study it can be concluded that the ethanolic extract of leaves of Boerhavia diffusa possess a favourable antidiabetic effect.