Potential Role of Zamzam Water in Some Chronic Diseases in Rats

Amal S Abdel-Azeem; Adel-Elsayed Mubarak; Yahya Abd-Elmonem Abd-Elhady; Asmaa Gaber Mohammed Badawi

Amal S Abdel-Azeem Nutrition and Food Science Dep., National Research Centre, Dokki, Cairo, Egypt
Adel-Elsayed Mubarak Nutrition and Food Science Dep., National Research Centre, Dokki, Cairo, Egypt
Yahya Abd-Elmonem Abd-Elhady Home Economics Dep., Faculty of Specific Education, Minufiya University
Asmaa Gaber Mohammed Badawi Home Economics Dep., Faculty of Specific Education, Minufiya University

Keywords: Zamzam water – Diabetes mellitus – Nephrotoxicity - Hepatotoxicity – Glucose – Liver markers – Kidney markers.

Abstract

Water from holy zamzam is consumed by many Muslims in the world due to its beneficial role for the health of human beings. Therefore the present study was designed to evaluate the effect of zamzam water in diabetes mellitus, nephrotoxicity and hepatotoxicity in rats as well as to determine the chemical analysis of this water. Fifty six male albino rats weighting (150±5gm) were divided into four main groups and each group was divided into two subgroups a and b, one administered tap water (Tw) and the other subgroup administered zamzam water (zw). The 1st main group was normal rat (-ve control), the 2nd group was diabetic (induced by alloxan 150 mg/kg b.w.), the 3rd was nephrotoxic (induced by gentamicin 100 mg/kg b.w.) and the 4th group was hepatotoxic by carbon tetrachloride (2ml/ kg b.w.). The experiment lasted after four weeks. Zamzam water significantly decreased serum glucose, total lipids, total cholesterol, triglycerides, LDL-cholesterol and elevated HDL- cholesterol. Moreover the liver and kidney markers were also improved in the groups that treated with zamzam water relative to its control taking tap water. Zamzam water has a protective role against hazardous effects of diabetes mellitus, nephrotoxicity and hepatotoxicity in rats.