The Effect of Modified Release Dosage Forms on Absorption of Medications

Heyam Saad Ali; Rasha Saad Suliman; Babiker M A Elhaj; Raina Suliman

Heyam Saad Ali Department of Pharmaceutics and Pharmacy Practice, Dubai Pharmacy College, Dubai, United Arab Emirates
Rasha Saad Suliman College of Pharmacy, King Saud bin Abdulaziz University for Health Sciences Ministry of National Guard Health Affairs, Riyadh, Kingdom of Saudi Arabia
Babiker M A Elhaj Pharmaceutical Sciences, College of Pharmacy Ajman University of Science and Technology.
Raina Suliman College of Sciences, Princess Nourah Bint Abdulrahman University.

Keywords: Modified Release drug delivery, absorption, patients’ compliance.

Abstract

Pharmaceutical industries focus on enhancing patients’ compliance by reducing dosing frequency and minimizing side effects. People above 40s year are frequently experiencing potential drug-drug interaction during combination therapy poly-therapy of once- daily formulations. The market is progressing rapidly in modified release technological advancements in improving bioavailability of drug delivery systems by controlling the erratic drug-release and plasma-concentration profiles. Consequently, enhancing patient compliance, cost effective and minimizing side effects and toxicities. This review focusing on the classification of different modified release drug dosage forms with their plasma-concentration profiles associated with absorption and changes in controlling and management of diseases.