Assessment of Rose Water and Evaluation of Antioxidant and Anti-inflammatory Properties of a Rose Water Based Cream Formulation

Abstract

Photo-aging is a universal dilemma that occurs in our population due to constant contact with ultraviolet radiation. The utilization of antioxidants is a successful approach to avoid symptoms associated to the photo-induced aging of the skin. In view of this, present study was designed to prepare and evaluate the antioxidant and anti-inflammatory activity of cream comprising the aqueous petals extract of Rosa damascena for its radical scavenging and protein denaturation activity. Antioxidant activity assessed using standard ascorbic acid (ferric reducing power assay), and anti-inflammatory activity assessed using standard diclofenac sodium measuring of the %age inhibition of protein denaturation. The rose water contains the major phytoconstituents which are polyphenolic compounds flavonoids, tannins, triterpenoids, saponins which are mainly responsible for the antioxidant and anti-inflammatory properties. Out of three cream formulations (F1, F2, and F3). F1 cream formulation showed the highest antioxidant (81.55%) and anti-inflammatory activity (80.6%) at 1000μg/ml. the result noted to be concentration dependent. The IC 50 value of F1 formulation cream was 257.39 while for F2 cream formulation 374.41. The present results indicate that the Rosa damascena petals extract (Rose water) has a good potential for cosmetic product development.