Formulation and Optimisation of pH-Dependent Drug Delivery System Containing Proton Pump Inhibitor
Keywords: Coating, Compatibility, Peptic Ulcer, Proton Pump Inhibitor.
AbstractThe objective of the current study was to formulate, evaluate, and optimize polymer coated pellets of rabeprazole. Rabeprazole is one of the productive drugs which show more effectiveness. Proton pump inhibitors are mostly used in ulcerative colitis. Rabeprazole acts by inhibiting last step of acid production. Rate of degradation of Rabeprazole increases as pH range decreases. Stability condition of proton pump inhibitor also affects by moisture content. Hence in current study, rabeprazole pellets were formulated and seal coat and polymer coat were loaded on pellets to protect from humidity and acidic condition. Rabeprazole was characterized by ultra violet spectroscopy (UV), fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC) study. Drug-excipient compatibility study carried out by FTIR. Opadry was used for seal coating of pellet and Eudragit L100 was used as polymer coat. Optimized batch passes all evaluation tests. Stability data shows an excellent result.
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