Evaluation of Homocysteine Levels in Patients with Psoriasis Vulgaris – A Case Control Study from Tertiary Care Hospital in North India
Keywords: Case control study, Exfoliative dermatitis, Homocysteine, Psoriasis.
AbstractBackground: Psoriasis is a chronic inflammatory disease that is non-contagious in nature, primarily involving skin and joints. The association of psoriasis with obesity, metabolic syndrome and cardiac problems has been suggested in recent data. Various biochemical markers are of prognostic significance in psoriasis, and out of these, raised homocysteine levels have been reported in various studies. However, some studies have shown no difference in Homocysteine levels in psoriasis patients. Hence, we planned this study to evaluate serum homocysteine levels in psoriasis vulgaris. Objective: To estimate and compare the serum homocysteine levels in psoriasis vulgaris patients and healthy controls and find any association between the homocysteine levels and severity of the psoriasis vulgaris. Material and Methods: One hundred clinically diagnosed patients of psoriasis vulgaris along with hundred age and sex-matched healthy controls were enrolled and assessed for serum homocysteine levels. Results: In this study, there was highly significant difference in the mean homocysteine levels between cases (13.60 ± 11.72) and controls (16.02 ± 11.32) and this difference was statistically highly significant (p less than 0.0001). We also compared the homocysteine levels in cases and controls based on their demographic profile like age group, gender, occupation, region and in cases based on the disease-specific parameters like duration of disease, family history, nail involvement, joint involvement, age of onset, body surface area and PASI. We observed that homocysteine levels were significantly higher in cases than controls when compared according to gender, region and PASI, and the difference was found to be statistically significant. Conclusion: Psoriasis has a significant effect on serum homocysteine levels and various studies have reported the risk of cardiovascular diseases with an increase in homocysteine levels. Our study suggests the relationship between psoriasis and serum homocysteine levels and further investigation is required to evaluate the role of serum homocysteine as a cardiac biomarker in patients with psoriasis.
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