The Excision Repair Cross-complementation Group 2 (rs1799793) Gene Polymorphism in Type 2 Diabetes Mellitus Patients
Keywords: ERCC2 (rs1799793), Polymorphism, Type 2 diabetes mellitus.
AbstractThe excision repair cross-complementation group 2 (ERCC2) or (XPD) gene encoded to protein used in bulky deoxyribonucleic acid (DNA) lesion removal from DNA, the present study used polymerase chain reaction single-strand conformation polymorphism (PCR-SSCP) to study ERCC2 polymorphism by haplotypes variations between DM2 patients and control group in addition to detect the glycemic parameters. The results show a significant increase in all glycemic parameters in the patient group except insulin resistance that significant decrease. The ERCC2 gene polymorphism shows three haplotypes (A, B and C), two patterns for patients and control observed; AC was more frequent in patients (46.34%) than control (17.24%) in significant differences (or 4.1455, p > 0.0147) and less frequent of ABC patterns in patients (53.65%) than control (82.75%). The polymorphism did not affect glycemic parameters. From this finding can be concluded that there was association between ERCC2 rs1799793 and DM2 but did not affect glycemic parameters.
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