The Combination Between Anti-depressant and Anti-diabetic Therapy Effects in Depressed Patients with Type 2 Diabetic Mellitus

  • Mona N. Al-Terehi College of Science, University of Babylon, Hillah, Iraq
  • Usama S. Altimari Al-Nisour University College, Baghdad, Iraq
  • Abed J. Kadhim Al-Nisour University College, Baghdad, Iraq
  • Hadeel Alaa Al-Rrubaei DNA Research Center, University of Babylon, Hillah, Iraq
Keywords: Anti-depressed, Anti-diabetic, Combination, Depression with type 2 Diabetic Mellitus, Therapy.


The current study aims to evaluate the effect of medication types in dopamine and glycemic parameters in patients with type 2 diabetic mellitus (T2DM), anti-diabetic, anti-depressed and combination between them, also the types of drugs were depended, metformin, metformin with insulin, insulin only, metformin with alprazolam and other anti-depressed drugs. Results show non-significant differences in all variations, metformin elevated dopamine, insulin and HbA1c than other types, metformin with insulin treatment recorded moderate level of all parameters, also moderate levels was observed in metformin with anti-depressed drug treatment the other anti-depressed drug decreased in dopamine level and elevated fasting blood glucose (FBG), interventional radiology (IR) and hemoglobin A1c (HbA1c) than other types, the effects of medication types show non-significant differences among all groups, the anti- depressed cause elevation in FBG and IR while dopamine was decreased than other two groups. Diabetic with Anti-depressed drug causes decrease in dopamine than the group of anti-diabetic drug only. The antidiabetic drugs have poor activity to regulate glycemic parameters and dopamine was in higher level than other groups in present study, from these outputs can be concluded that the combination between anti-depressed and anti-diabetic therapy with suitable choosing of the drug may prevent disease complications and enhanced self-care of patients.