The Glutathione S-Transferasee (GSTT and GSTM) Genotyping and Alcohol Level in Drunks

  • Mona N. Al-Terehi College of Science, University of Babylon, Hillah, Iraq
  • Usama S. Altimari Al-Nisour University College, Baghdad, Iraq
  • Abed J. Kadhim Al-Nisour University College, Baghdad, Iraq
  • Aamal M. Kadhum Medical Laboratories Techniques Department, Al-Mustaqbal University College, Iraq
Keywords: Glutathione S-Transferase, GSTT, GSTM, Genotyping, Alcohol Level, Drinking Habbit.

Abstract

Alcoholism is most the important problem is spreading among the young in the Iraqi population, studies found the health and social harmful effects of alcohol thus the present study deal with The Glutathioe S-Transferase in alcohol use disorder, the GSTT and GSTM genotyping was used in the current study, the current finding showed GSTT+GSTT was present in low percent in drunks than the control group in non-significant differences (p = 0.156). the GSTT found in high percent’s in drunks and control with null genotyping observed in non-significant differences (p = 0.801), the GSTM found in low percent in the drunks than control and null genotyping was higher in drunks than control in significant differences (p = 0.009). and finally the GSTT null GSTM and GSTM null GSTT were significant differences (p = 0.021), The levels of alcohol was detected according to GST genotyping, the high level of alcohol observed in GSTT+GSTM null genotyping (96.25 ± 22.58) while low percent observed (62.00 ± 2.00) in GSTM null GSTT, all differences were non-significant, it can be concluded that the GSTM null genotyping was strong association with alcohol use disorder, and the null genotyping of both GSTs genes have higher levels of alcohol than other genotyping.
Published
2021-06-25