The Genotyping Impact of X-ray Repair Cross-Complementing Group 1 Gene in Systemic Lupus Erythematosus

  • Mona N. Al-Terehi College of Science, University of Babylon, Hillah, Iraq
  • Zuhair I. Al Mashhadani Al-Nisour University College, Baghdad, Iraq
  • Muneam H. Ali Al-Nisour University College, Baghdad, Iraq
Keywords: DNA repair, XRCC1, Arg399Gln, Genotyping, Systemic Lupus Erythematosus.


DNA repair genes have a vital role in a variety of diseases. The present investigates deal with X-ray repair cross-complementing group 1 gene (XRCC1 Arg399Gln) in systemic lupus erythematosus (SLE). PCR-CTPP method used to detect polymorphism, the results show two alleles (A and G) and three genotyping (AA, AG, and GG), the present analysis shows that non-significant association between (AG and GG) with SLE patients (p = 0.3964), strong association with absent AA in patients than control (10%) in significant differences (p = 0.0322). can be concluded that the XRCC1 Arg399Gln may be affected in the SLE in Iraqi patients.