The tRNAleu Gene Variation in Systemic Lupus Erythematosus Patients
Keywords: Gene variation, Systematic lupus erythematosus, The tRNAleu.
AbstractThe systematic lupus erythematosus (SLE) is an autoimmune disease characterized by the immune molecules attach its own tissue. The present research implemented to detection tRNAleu gene variation in SLE by case control study. polymerase chain reaction (PCR)-sequencing used to detection mutation, results show strong association between tRNAleu encoded gene and SLE disease and this represented by the high percentage of variation in patient than control group, deletion mutation were 80 nucleotides in patients and 50 nucleotides in the control group, and substitution mutations were 103 nucleotides in patients and 81 nucleotides in the control group, the different types of substitution mutations included (G>A, G>T, G>C, A>G, A>T, A>C, C>A, C>G, C>T, T>G, T>A and T>C) in significant differences (p = 0.007), the present study concludes that the variations in tRNAleu gene may be effect in the tRNA folding that lead to effect in amino acid transfer during protein synthesis.
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