Synthesis and Evaluation of Antibacterial and Antifungal Profile of some Newer Isoxazole Analogous

Abstract

A new series of 5-(chloromethyl)-3- (substituted phenyl) isoxazole was synthesized in the presence of sodium hydroxide, substituted aromatic aldehyde (1) combine to produce oxime (2), which are then cyclized in the presence of dichloromethane, triethylamine, and N-chlorosuccinimide to develop Compound (3) and on chlorination onward 5-(chloromethyl)-3- (substituted phenyl) isoxazole (4). By employing IR, 1H-NMR, mass spectral, and elemental analyses, the chemical compositions of the generated molecules were verified. The developed molecules were tested for their antibacterial properties (E. coli & S. aureus), antifungal (A. niger and C. albicans). The new compound demonstrated considerable antibacterial and antifungal activity on level with standards set.