Implications of Biodegradable and Bioadhesive Systems in Colon Delivery

Abstract

Oral or non-parental drug delivery systems are widely used for the administration of therapeutic drugs. However, the gastrointestinal tract presents several barriers to anticancer drugs in targeting colon cancer. Colonic drug delivery has gained increased importance not just for the delivery of the drugs for the treatment of local diseases associated with the colon but also for its potential for the delivery of proteins and therapeutic peptides. To achieve successful colonic delivery, which is considered to be the optimum site for colon-targeted delivery of drugs, colon targeting is of prime importance for the topical treatment of diseases of colon such as Chorn's diseases, ulcerative colitis, colorectal cancer and amebiasis. Peptides, proteins, oligonucleotides and vaccines pose potential candidature for colon targeted drug delivery.