Pharmacological Activities of ‘Chandrakhya’Leaves

Ashish Singhai; P. K. Singour; R. S. Pawar; U. K. Patil

doi:10.25004/IJPSDR.2009.010211

Ashish Singhai Department of Pharmacognosy and Phytochemistry, VNS Institute of Pharmacy, Neelbud, 462004, Bhopal, India.
P. K. Singour Department of Pharmacognosy and Phytochemistry, VNS Institute of Pharmacy, Neelbud, 462004, Bhopal, India.
R. S. Pawar Department of Pharmacognosy and Phytochemistry, VNS Institute of Pharmacy, Neelbud, 462004, Bhopal, India.
U. K. Patil Department of Pharmacognosy and Phytochemistry, VNS Institute of Pharmacy, Neelbud, 462004, Bhopal, India.

DOI: https://doi.org/10.25004/IJPSDR.2009.010211

Keywords: Zingiber officinale,analgesic, anti-bacterial, anti-fungal.

Abstract

The herbal drug ‘Chandrakhya’ is commonly used in Indian traditional medicine for thousands of years. Various activities of its rhizome have been reported by several researchers but the studies on leaves are not yet reported. The aim of this study is to explore the analgesic, antibacterial and an antifungal activity of Zingiber officinale (ZO) [Chandrakhya] leaves on albino rats. Aqueous and alcoholic extracts of Zingiber officinaleleaves were selected at different doses and analgesic activity was evaluated by acetic acid induced writhing test and tail clip method. The anti-bacterial and anti-fungal activity of the ZO leaves was evaluated by employing well diffusion method against S. aureus, E.coli, P.vulgaris and C. albicans. It was found that the aqueous and alcoholic extracts at the dose of 400mg/kg showed significant analgesic activity as well as shown significant anti-bacterial and anti-fungal activity at the dose of 40 mg/ml. The present study shows the usefulness of the leaves of Zingiber officinale and indicates that its alcoholic extract is more active than the aqueous extract in analgesic, antibacterial and antifungal activities.