Possible Pharmacological Basis for Antithrombotic Effect of Glycyrrhiza Glabrain Sprague Dawley Rats

M. Jain; A. Yadav; V. Tomar; P. Kannojia; S.S. Solanki; S.D. Tonpay

doi:10.25004/IJPSDR.2009.010213

M. Jain CDRI, Lucknow,India.
A. Yadav BITS, Pilani, Rajasthan,India.
V. Tomar Intitute of Professional Studies, Shivpuri Link Road, Gwalior-474002 M.P. India.
P. Kannojia Intitute of Professional Studies, Shivpuri Link Road, Gwalior-474002 M.P. India.
S.S. Solanki Intitute of Professional Studies, Shivpuri Link Road, Gwalior-474002 M.P. India.
S.D. Tonpay G.R. Medical College, Department of Pharmacology, Gwalior-474002M.P.,India.

DOI: https://doi.org/10.25004/IJPSDR.2009.010213

Keywords: Glycyrrhiza glabra, Thrombin, Venous thrombosis, Rats.

Abstract

It has been previously identified that 3-aryl comarin derivative, GU-7 isolated from Liquorice posses Antiplatelet activity. It inhibits platelet aggregation by increasing intraplatelet cyclic AMP concentration. Here we report the in-vivo effects of extract of Glycyrrhiza glabraand also the combined effect with Vitamin K and Heparin. Extract of Glycyrrhiza glabraincreased the bleeding time when given in the doses of 180mg/kg and 360mg/kg. Blood loss was evaluated 60 minute later as a function of absorbance at 540 nm due to hemoglobin content in water solution. Altogether data indicates that Glycyrrhiza glabrais an effective anti thrombotic agent in vivo, which may account for its known pharmacological properties.