Formulation and Evaluation of Neomycin Sulphate Ointment containing Natural Wound Healing Agent Curcuma longa

Abstract

Present investigation was to develop novel ointment formulation in combination of natural wound healing agent curcuma longa, which is reported to possess wound healing and anti-bacterial activities.Combination of neomycin sulphate and curcuma longa is good rational, where curcuma longa produces synergistic wound healing effect with neomycin sulphate. Formulations containing fixed concentration (0.5 %) of neomycin sulphate and 3 %, 4 % and 5 % of curcuma longa were prepared. To assess the efficacy of formulations anti-bacterial activity, rheology, stability, spreadability and other physicalcharacteristics were evaluated. The results obtained were encouraging and formulation containing neomycin sulphate (0.5 %) with 5 % of curcuma longa was found better than other formulations.