Synthesis and Biological Activity of 2-(Thiazolidin-4-One) Phenyl]-1h-Phenylbenzimidazoles and 2-[4-(Azetidin-2-One)-3-Chloro-4- Phenyl] -1h-Phenyl Benzimidazoles.

P. Shanmugapandiyana; K.S. Denshingb; R. Ilavarasanc; N. Anbalagand; R. Nirmal

doi:10.25004/IJPSDR.2010.020206

P. Shanmugapandiyana Department of Pharmaceutical Chemistry, Balaji Institute of Pharmacy, Laknepally, Narsampet, Warangal, Andhra Pradesh, India.
K.S. Denshingb Department of Pharmacology, C. L. Baid Metha College Of Pharmacy, Old mahabalipuram road, Thoraipakkam, Chennai-600 096, Tamilnadu, India.
R. Ilavarasanc Department of Pharmacology, Captain Srinivsa Muurti Drug Research Institute for Ayurveda and Siddha, Arumbakkam, Chennai-600106, Tamilnadu, India.
N. Anbalagand Department of Pharmaceutical Chemistry, Pydah College of Pharmacy, 2-360, Patavala, Kakinada-533127, Andhra Pradesh, India.
R. Nirmal Department of Pharmaceutical Chemistry, Balaji Institute of Pharmacy, Laknepally, Narsampet, Warangal, Andhra Pradesh, India.

DOI: https://doi.org/10.25004/IJPSDR.2010.020206

Keywords: Azetidinone, Thiazolidinone, Benzimidazole, Analgesic, Anti-inflammatory, Antibacterial, Antifungal.

Abstract

A new series of 2-[4-(azetidin-2-one)-3-Chloro-4-phenyl]-1H-Phenylbenzimidazolesand 2-(thiazolidin-4-one)-Phenyl]-1H-Phenylbenzimidazoles were synthesized by the reaction of schiff base [2-(4-aminophenyl)-Benzimidazole and substituted Benzaldehyde] with chloroacetyl chloride and mercaptoacetic acid respectively. The chemical structures of the synthesized compounds were confirmed by IR, 1H-NMR, mass spectral and C, H, N analysis. The synthesized compounds were screened for antibacterial (Bacillus cereus, Escherichia coli, Micrococcusluteus,Klebssiela pneumoniae, Staphylococcus aureus and Salmonella epidermidis),antifungal (Aspergillus niger and Candida albicans), analgesic activity by writhing reflex method and anti-inflammatory activity by carrageenan induced paw edema method. The synthesized compound showed significant activity of antibacterial, antifungal, analgesic and anti-inflammatory activity comparable to that of standard.