Evaluation of Anti-inflammatory Activity of Trichosanthes dioica Roxb. Seeds

Abstract

Inflammation a complex disease associated with various symptoms. These symptoms can be managed with non-steroidal and steroidal anti-inflammatory drugs, which lead to severe side effects on long-term use. Natural products are used as an alternative source of the discovery of new entities to be used as compounds anti-inflammatory compounds to overcome this problem. Trichosanthes diocia (T. diocia) belongs to Cucurbitaceae family. T. dioica, a dioecious perennial herbaceous vegetable, is a rich source of vitamin C and minerals. In addition to fruits, leaves and tender shoots have been used in the indigenous system of medicine. The objective of the present study was to evaluate the anti-inflammatory activity of methanolic extract of T. dioica seeds for scientific validation of the folklore claim of the plant The extract was evaluated at three different concentrations of 100, 200, and 400 mg/kg, p.o. Significant dose-dependent anti-inflammatory activity was observed, comparable with that of the standard drug indomethacin at a dose of 10 mg/kg.