Screening of Antidiabetic Activity of Extract and Fraction of Biophytum sensitivum in Rats Using STZ-Nicotinamide Induced Diabetes Model

Manisha ., Kumar Suresh

Abstract


The study was aimed at investigate the effect of methanolic extract of Phaseolus semierectus(L.) (Leguminosae) on general
mating behaviour, libido, and adverse effects on sexually normal male albino rats. Methanolic extract was administered
orally at the dose of 100, 200, and 400 mg / kg, to different groups of male rats (n = 8) once a day for 14 days. All the
doses resulted in significant increase in mount frequency, intromission frequency and anogenital sniffing when compared
to normal. The methanolic extract of Phaseolus semierectus (L.) seeds at higher concentration (400 mg/kg body weight)
showed significant aphrodisiac activity on male Wister albino rats as evidenced by an increase in number of mounts and
mating performance. Thus, in experimental rats, the results of the present study suggest that the methanolic extracts of
Phaseolus semierectus (L.) exert significant aphrodisiac activity.

Keywords


Antidiabetic, Biophytum sensitivum, Ethyl acetate fraction, Phytochemical screening.

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DOI: https://doi.org/10.25258/ijtpr.v9i03.9079

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