Possible Mechanisms of Endothelioproteсtion 4-Hydroxy-3,5-DiTretbutyl Cinnamic Acid in the Cerebral Ischemia in Experiment

D. I. Pozdnyakov, A. V. Voronkov, D. S. Zolotych

Abstract


Conducted research devoted to the study of potential mechanisms of action implementation endotelioproteсtion 4-hydroxy-
3,5-di-tretbutyl cinnamic acid in experimental conditions simulated cerebral ischemia in rats. The research found that the
cerebral ischemia in rats is accompanied by the development of endothelial dysfunction, expressed in increasing the
concentration of asymmetric dimethylarginine, nNOS, iNOS and PKC, as well as reducing the concentration of eNOS.
Introduction of sulodexide (to a greater extent compared with thioctic acid and mexidol restores endothelial function in
conditions of brain ischemia in rats. The use of 4-hydroxy-3,5-di-tretbutyl cinnamic acid helped reduce the concentration
of ADMA, nNOS, iNOS and PKC on 83.9% (p >0.05), 60.6% (p >0.05), 61. 9% (p >0.05), 108.6% (p >0.05), respectively,
as well as improve the content of eNOS at 114.2% (p >0.05), thereby contributing to the correction that has developed in
conditions cerebral ischemia, endothelium dysfunction

Keywords


cerebral ischemia, endothelial dysfunction, endotelioprotection, immunoassay.

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DOI: https://doi.org/10.25258/ijtpr.v9i03.9222

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