INVESTIGATION OF HYPOGLYCAEMIC ACTIVITY OF SOME MYANMAR MEDICINAL PLANTS

Ngu Wah Thinn; Zaw Khaing OO; Saw Sandar Maw

doi:10.30780/IJTRS.V3.I3.2018.011

Ngu Wah Thinn Department of Biotechnology, Mandalay Technological University, Mandalay, Myanmar
Zaw Khaing OO Department of Biotechnology, Mandalay Technological University, Mandalay, Myanmar
Saw Sandar Maw Department of Biotechnology, Mandalay Technological University, Mandalay, Myanmar

DOI: https://doi.org/10.30780/IJTRS.V3.I3.2018.011

Keywords: Orthosiphon aristatus (Blume) Miq., Andrographis paniculata (Nees), Azadirachta indica (A.Juss) and hypoglycaemic activity.

Abstract

The hypoglycaemic activities of three ethanolic extracts prepared from leave of Orthosiphon aristatus (Blume) Miq., Andrographis paniculata (Nees) and bark of Azadirachta indica (A.Juss) were investigated in this study. According to preliminary phytochemical examination, the three plants showed the absence of cyanogenic glycosides and the presence of antibiotic potential of constituents. In vitro and vivo toxicity test, these selected plants were potentially safe for medicinal use. Among these three extracts, O. aristatus showed the most significant reduction in fasting blood glucose (FBG) levels on tested mice according to the results from hypoglycaemic activity. But A.indica extracts could not be lowers the fasting blood glucose levels significantly. The extracts of O. aristatus and A. paniculata were further fractionated by trituration method into three solvent portions. According to overall results, A. paniculata plant has validated for the treatment of diabetes mellitus.