A Case Report: NF1, NPM1 and IDH1 Positive Relapse Acute Myeloid Leukemia

Abstract

Background: Acute myeloid leukemia (AML) is a type of hematological malignancy that affect vital age group from 20-49 years with a broad variety of symptoms including low-grade fever, toothache, easy bruising and lifethreatening conditions. This case will be first time in Bangladesh presented with molecular basis and life expectancy of adult AML after chemotherapy Case Presentation: This study reports a relapse case of AML 38 years Bangladeshi female who presented with weakness, fatigue, fever and gum swelling. She was diagnosed as a case of AML NPM1 positive on the basis of peripheral blood finding, bone marrow examination report and immune phenotyping. After relapse, the whole genome sequencing for AML was done and report shows it had other associated genetic NF1, IDH1 and DNM3T abnormalities. She got chemotherapy 3+7 induction protocol followed by 3HiDAC consolidation protocol. During relapse time, started azacitidine and vanetoclax therapy. After receiving two cycle, symptom not subsided and died. Conclusion: Now a days, AML is treated on molecular basis. If the patient of this case, is diagnosed by whole genome sequencing of AML before her chemotherapy her prognosis will be better and life expectancy will increase.