To Evaluate Synergetic Potential of Piperine with Citalopram on Chronic Unpredictable Mild Stress- Induced Depression in Wistar Rats

Katta Sunand; Lankadasari Divya Shree; Matla Harika; Meesala Basanti; Merugu Manisha; Nerella Mounika; Vasudha Bakshi; G. Krishna Mohan

doi:10.21477/ijapsr.4.4.2

Katta Sunand Assistant Professor, Department of Pharmacology, Anurag University, Telangana, India
Lankadasari Divya Shree Student, Department of Pharmacology, Anurag University, Telangana, India
Matla Harika Student, Department of Pharmacology, Anurag University, Telangana, India
Meesala Basanti Student, Department of Pharmacology, Anurag University, Telangana, India
Merugu Manisha Student, Department of Pharmacology, Anurag University, Telangana, India
Nerella Mounika Assistant Professor, Department of Pharmacology, Anurag University, Telangana, India
Vasudha Bakshi Dean, Department of Pharmacology, Anurag University, Telangana, India
G. Krishna Mohan Centre for Pharmaceutical Sciences, Institute of Science and Technology, JNTU Hyderabad, India

DOI: https://doi.org/10.21477/ijapsr.4.4.2

Keywords: Chronic unpredictable mild stress, Citalopram, Depression, Piperine, Wistar rats.

Abstract

Depression is a neurological and mood disorder identified by a discouraged state of mind and low confidence, influencing the cognitive and social wellness of an individual. An imbalance in the monoamine neurotransmit¬ters leads to depression. Selective serotonin reuptake inhibitors drugs are the generally recommended anti-depressants as they enhance the levels of serotonin in the brain. The efficiency of selective serotonin reuptake inhibitors (SSRIs) in mild or moderate cases of depression has been disputed. In this study, co-administration of piperine, along with citalopram, was evaluated. Citalopram, in combination with piperine, possesses effective potency to improve the behavioral imperfections through forced swim test (FST), tail suspension test (TST), and acto-photometer behavioral tests. Thus, the results revealed that a combination of piperine with citalopram has excellent beneficial effects than an individual in the treatment of depression. This synergetic effect of piperine with citalopram may attribute to their inhibitory activity of the CYP450 enzymes.