Synthesis and Antiangiogenic Activity of some Novel Combretastatin A-4 analogues

Anurag; S. N. Pandeya; U. K. Singh; P. P. Sharma

Anurag Dr. K. N. Modi Institute of Pharmaceutical Education and Research, Modinagar-201201, Uttar Pradesh, India
S. N. Pandeya Dr. K. N. Modi Institute of Pharmaceutical Education and Research, Modinagar-201201, Uttar Pradesh, India
U. K. Singh Dr. K. N. Modi Institute of Pharmaceutical Education and Research, Modinagar-201201, Uttar Pradesh, India
P. P. Sharma Dr. K. N. Modi Institute of Pharmaceutical Education and Research, Modinagar-201201, Uttar Pradesh, India

Keywords: Combretastatin A-4, antiangiogenic, cytotoxicity, anticancer, antitubulin.

Abstract

A series of Combretastatin A-4 analogues were synthesized in order to obtain new compounds with potential antiangiogenic activity. The structures of all synthesized compounds were confirmed by means of spectroscopical analytical techniques. All compounds were evaluated for their antiangiogenic activity by chorioallantoic membrane (CAM) assay method. The compounds showed significant antiangiogenic activity. Compound 5 showed maximum activity out of all synthesized compounds.