Evaluation of Medicinal Properties of Hibiscus rosa sinensis in Male Swiss Albino Mice

Abstract

The present study was undertaken to evaluate the medicinal properties of Hibiscus rosa sinensis on male mice. For this Swiss albino mice were orally administered Hibiscus rosa sinensis (500 mg/kg of body weight) and effect of the treatment on, reproductive organ cholesterol level and glucose level. Recovery study was also carried out. The treatment caused reduction in the weight of testis, epididymis and evaluation of sperm count indicates that sperm density decreased significantly. Histologically, testis in mice treated with the plant extract showed alteration in the seminiferous tubules and alteration include decrease in thickness and density of germinal epithelium and hypertrophy in majority of cells moreover lumen shows negligible presence of sperms in the treated animal as compared to control. The treatment group had decrease in levels of testosterone. Crude extract of blooms of Hibiscus rosa sinensis possess hypoglycemic and hypocholestrolemic potentially. The alterations caused in the above endpoints by the plant extract were reversible and by 60 days of the treatment withdrawal, the parameters recovered to control levels. The results in Swiss albino mice thus suggest that Hibiscus rosa sinensis treatment causes reversible suppression of spermatogenesis, Cholesterol level and glucose level.