Synthesis and In-Vitro Anti-Microbial Activity of Some New N-Phenyl Acetamide Derivatives

Abstract

The purpose of the research work is to synthesised a new potent antimicrobial derivatives of N-phenyl acetamide. A series of new methyl 4-oxo-4-(Piperidine phenylamino) butanoate 4(a) and methyl 4-oxo-4-(Imidazole phenylamino) butanoate 4(b) were synthesized by treating N -Phenyl acetamide with methyl choloroacetate in the presence of anhydrous potassium carbonate to give an intermediate compound (3) which on further treatrment with piperidine and imidazole at 70oC temperature gives the new compounds 4(a) and 4(b) respectively. The structures of newly synthesised derivatives were confirmed on the basis of Melting Point, TLC, IR, NMR and spectral data. The anti microbial activity of the synthesized compounds was evaluated by Disc diffusion test.