New Trends of Diabetes Therapy type II of the Animal Model

  • Humaira Farooqi Department of Pharmacognosy and Phytochemistry , Research Laboratory, Faculty of Pharmacy, Jamia Hamdard (Hamdard University) Hamdard Nagar, New-Delhi- 110062, India
  • Hamid Nawaz Khan Department of Pharmacognosy and Phytochemistry , Research Laboratory, Faculty of Pharmacy, Jamia Hamdard (Hamdard University) Hamdard Nagar, New-Delhi- 110062, India
  • Richa Gupta Department of Pharmacognosy and Phytochemistry , Research Laboratory, Faculty of Pharmacy, Jamia Hamdard (Hamdard University) Hamdard Nagar, New-Delhi- 110062, India
  • Anwar Habib Department of Pharmacognosy and Phytochemistry , Research Laboratory, Faculty of Pharmacy, Jamia Hamdard (Hamdard University) Hamdard Nagar, New-Delhi- 110062, India
  • Parwaiz Akhtar Department of Pharmacognosy and Phytochemistry , Research Laboratory, Faculty of Pharmacy, Jamia Hamdard (Hamdard University) Hamdard Nagar, New-Delhi- 110062, India
  • Showkat Rasool Mir Department of Pharmacognosy and Phytochemistry , Research Laboratory, Faculty of Pharmacy, Jamia Hamdard (Hamdard University) Hamdard Nagar, New-Delhi- 110062, India
  • Kamran J. Naquvi Department of Pharmacognosy and Phytochemistry , Research Laboratory, Faculty of Pharmacy, Jamia Hamdard (Hamdard University) Hamdard Nagar, New-Delhi- 110062, India
Keywords: diabetes mellitus , secretagogues , Biguanides , thiazolidinediones , incretins , GLP 1 agonist , DPP 4 inhibitors , bariatric surgery , antidiabetic plants.

Abstract

There is a growing consensus that blood glucose control, and postprandial control in particular, must become more aggressive if we are to stem the growing tide of diabetes related complications and mortality. For most people, this means that insulin therapy must begin earlier and that insulin must be titrated sufficiently to achieve tighter glycemic targets. The limitations of traditional treatment regimens, delivery devices and conventional insulin formulations, in conjunction with patient factors, have prevented the majority of people with type-2 diabetes from achieving recommended glycemic targets. Fortunately, incretin mimetics, DPP-4 inhibitors and techniques like bariatric surgery are now available. This review will discuss features and of these new tools, compare the benefits of using these drugs versus conventional drugs and also the use of medicinal plants in this area. Once physicians become familiar with these tools and incorporate them into daily practice, they will be able to better tailor diabetes self-management programs to the needs of individual patients. The result will be that more patients should be able to reach recommended glycemic targets with greater convenience and safety than has previously been available. As this metabolic disorder is like an epidemic, intense research is required and many scientists are working on potential targets to control it.
Published
2010-06-25