Effect of Combination of Surfactant and Super Disintegrating Agent on In-vitro Disintegration and Dissolution Release Profile of Medroxyprogestrone Acetate Tablet

Abstract

The effects of selected surfactants and superdisintegrants on the disintegration behavior of selected model drug with varying combinations of excipient were evaluated. All formulations were made with fixed disintegrant concentration and equal drug load using a model formulation. Tablets were made by wet granulation and were compressed to equal hardness. In-vitro disintegration time and dissolution studies were carried out in dissolution media specified high performance liquid chromatography method. The use of Crosscarmellose sodium (Ac-di-Sol) significantly improved the disintegration time and dissolution of the drugs in the model formulation with or without surfactant, when compared with the other formulation. Crosscarmellose sodium (Ac-di-Sol) with combination of surfactant and disintegrating agent can be effectively used as a tablet disintegrant to improve the disintegration time and dissolution of either soluble or poorly soluble drugs.