Hepatoprotective Effect of Enicostemma littorale in Alcohol Induced Oxidative Stress in Male Albino Rats

Srinivasan P. Barani; R. S. Sreenivasan

Srinivasan P. Barani Department of Biomedical Engineering, Rajiv Gandhi College of Engineering and Technology, Puducherry- 607 402, India
R. S. Sreenivasan Department of Biomedical Engineering, Rajiv Gandhi College of Engineering and Technology, Puducherry- 607 402, India

Keywords: Enicostemma littorale, aqueous extract, oxidative stress, superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione-S-transferase (GST).

Abstract

The aqueous extract obtained from the leaves of Enicostemma littorale Blume (Gentianaceae) was investigated for antioxidant effect on ethanol induced oxidative stress in male albino rats. The decreased activity level of the antioxidant enzymes such as superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and glutathione-S-transferase (GST) in the liver tissue of ethanol fed rat recorded elevated activity levels after the administration of leaf extract. The inhibition of lipid peroxide production in the treated animals showed an improved antioxidant status.