Effect of Sinapic acid on Antiperoxidative and Antioxidant Potential in Normal and Streptozotocin-induced Diabetes in Wistar Rats

Abstract

The present study was aimed to investigate the effect of Sinapic acid on antioxidant potential in normal and Streptozotocin-induced diabetic rats. Diabetes was induced in female wistar rats by a single intraperitoneal administration of Streptozotocin (45 mg/ kg BW). Rats were divided into six groups: normal (untreated), normal + Sinapic acid (15mg/kg), normal + Sinapic acid (30 mg/kg), diabetic control, diabetic + Sinapic acid (15mg/kg) and diabetic + Sinapic acid (30 mg/kg). Diabetic rats exhibited elevated levels of lipid peroxidation markers such as thiobarbituric acid reactive substances and hydroperoxides in plasma and tissues and decreased levels of antioxidants superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPX), reduced glutathione (GSH), ceruloplasmin, vitamin C and vitamin E in serum and tissues. Oral administration of Sinapic acid for a period of 35 days significantly decreased lipid peroxidation markers and increased the antioxidants suggesting the antioxidant potential of Sinapic acid in diabetic rats.