Antiobesity Effect of Polyherbal Formulations in Cafeteria and Atherogenic Diet Induced Obesity in Rats

Abstract

A weight loss supplement containing Cissus quadrangularis and other ingredients including, Glycine angustifolia, Avena sativa and Spinacia oleracea was evaluated in a 6-week trial in female Wister rats fed on cafeteria and atherogenic diets. Polyherbal Formulation (PHF) was prepared and evaluated for physicochemical parameters. Female Wistar rats were fed cafeteria diet (highly palatable, energy rich animal diet that includes a variety of human snack foods) and atherogenic diet for 6-week. Polyherbal formulation was administered in a dose of 400 mg/kg, p.o., once daily to the drug treatment groups. The effect of Polyherbal formulation was recorded on the parameters like body weight, food and water intake, behavioral activity and various biochemical parameters like serum glucose, total cholesterol and triglyceride levels. Significant reduction in body weight, behavioral activity and serum glucose levels after treatment was observed with Polyherbal formulation in cafeteria diet and atherogenic diet fed rats. Treatment with Polyherbal formulation also significantly decreased total cholesterol and triglyceride in rats fed with atherogenic diet. Polyherbal formulation had no adverse effect on behavioral parameter. The Polyherbal formulation helped reduce body weight by approx 20 - 25 % in animal fed on cafeteria and atherogenic diets.