A Study on the Pattern of Lipid Profile and Apolipoproteins in Patients With Diabetic Retinopathy

V. M. Vinodhini; S. Gnaneswaran; William W. Ebenezer; J. S. Kumar; A. Jeevanathan; D. V. Poonguzhali

V. M. Vinodhini Department of Biochemistry, SRM Medical College Hospital and Research Centre, Tamilnadu, India.
S. Gnaneswaran Department of Biochemistry, SRM Medical College Hospital and Research Centre, Tamilnadu, India.
William W. Ebenezer Department of Biochemistry, SRM Medical College Hospital and Research Centre, Tamilnadu, India.
J. S. Kumar Department of Biochemistry, SRM Medical College Hospital and Research Centre, Tamilnadu, India.
A. Jeevanathan Department of Biochemistry, SRM Medical College Hospital and Research Centre, Tamilnadu, India.
D. V. Poonguzhali Department of Biochemistry, SRM Medical College Hospital and Research Centre, Tamilnadu, India.

Keywords: Apolipoprotein AI, Apolipoprotein B, Diabetic Retinopathy, Type 2 diabetes mellitus.

Abstract

Dyslipidemia is found to be associated with the initiation and progression of diabetic retinopathy (DR). Modifications of lipoproteins by glycation and oxidation and the variations in the size distributions of lipoprotein particles are not reflected in conventional lipid profiles. This study was conducted to know if the measurements of apolipoprotein AI (apo AI) and apolipoprotein B (apo B) may be more directly relevant to the biophysiological changes associated with DR than the traditional lipids. The study subjects consisted of 30 type 2 diabetic patients with DR and 20 type 2 diabetic patients without DR. Diabetic retinopathy was determined by an ophthalmologist using fundoscopic examination. Serum levels of lipids and lipoproteins were measured by standard enzymatic methods. The apo B and apo AI levels did not differ significantly between the two groups. In this study, we did not find any relationship between serum apolipoprotein levels and diabetic retinopathy in type 2 diabetic patients.