Synthesis of Some New Azetidinones Derived from Heterocyclics and their Antimicrobial Activity

Abstract

This present work deals with the synthesis, characterization and biological activity of some new Azetidinones derived from heterocyclics. Different aryloxy acetic acd were obtained from different substituted or unsubstituted phenols upon treatment with chloro acetic acid in presence of sodium hydroxide. The aryloxy acids were converted to respective acid chlorides by treating with thionyl chloride in benzene. The acid chloride was straight away used for next step. The Schiff bases were obtained by reaction of 4-amino benoic acid with substituted aldehydes in acetic acid. Then Schiff bases on reaction with acid chloride gave different azetidinones. The final derivatives of the Azetidinones were obtained by reaction with 2-amino pyridine moiety which gave different Azetidinones derivatives. The structures of the newly synthesized compounds have been established on the basis of their spectral data and elemental analysis. The synthesized compounds were screened for antimicrobial activity by paper disc diffusion method. All compounds were evaluated for antimicrobial activities against Bacillus Pumilus, Bacillus Subtilis Staphylococcus aureus and Escherichia Coli. The potency of the synthesized compounds was determined against standard drug Ciprofloxacin by measuring the zone of inhibition and calculating the MIC.