Nitric Oxide in Diabetic Patients and its Relation with HbA1c

C. R. Naveen; P. Renuka

C. R. Naveen Dept. of biochemistry, SRM Medical College, Hospital and Research Center. Kattankalthur, Tamilnadu, India.603203.
P. Renuka Dept. of biochemistry, SRM Medical College, Hospital and Research Center. Kattankalthur, Tamilnadu, India.603203.

Keywords: Diabetes mellitus, glucose, nitric oxide, superoxide ion.

Abstract

In diabetic patients, hyperglycemia leads to many complications like arteriosclerosis and coronary artery disease. Nitric Oxide plays a major role in micro and macro vascular complications. NO which is produced by endothelial cells has very short half life making it less available. The present study is undertaken to evaluate NO and its metabolites levels in diabetic patients. Methodology: 55 diabetic patients attending diabetology consultant were compared with 25 controls attending OP, SRM Hospital. Serum NO and Urinary NO were estimated by griess method and FBS and HbA1c in AU400 autoanalyzer. Results: Serum and urinary NO level were increased in diabetic patients compared to controls.