N-Substituted Fluoro Benzothiazolo Schiff’s Bases: Synthesis and Characterisation of New Novel Anthelmintic Agents

Abstract

Various substituted N-[6-fluoro-7-substituted benzothiazol-2-yl]-2-(furan-2-yl methylene) hydrazine carbothioamide containing different functional groups have been synthesized by treating fluoro chloro aniline with KSCN in presence of bromine in glacial acetic acid and ammonia to get 2-amino-6-fluoro-7-chloro-(1,3)- benzothiazole, which was treated with hydrazine hydrate, carbondisulphide and sodium chloro acetate in the presence of ethanol to get N-(7-chloro-6- fluoro benzothiazol-2-yl) hydrazine carbothioamide, which will refluxed with furfuraldehyde in the presence of ethanol to get newly N-(6-fluoro-7-chloro benzothiazol-2-yl)-2-(furan-2-yl methylene) hydrazine carbothioamide or schiff’ base. To the above schiff’s base different substitutents in presence of Dimethyl formamide (DMF) were treated to get newly targeted compounds through replacing at 7th position of chlorine. The lead compounds were characterized by Melting point, TLC, calculated elemental analysis, UV, IR, and H1 NMR spectral studies. The synthesized compounds were treated for anthelmintic activity against Earthworms (perituma posthuma) nearly equal size had shown significant activity at different concentrations compared to standard; still further studies are requested.