Correlation Between Insulin Resistance and Obesity in Normoglycemic Obese Syrian Subjects

Abstract

Insulin resistance is a pathophysiologic link to development of several metabolic disorders in obese subjects. The aim of this study is to evaluate the association between obesity and insulin resistance using HOMA-IR index in normoglycemic obese subjects and to compare the results with the result of healthy non obese subjects. The importance is to identify the subjects in risk for developing preventive strategies before the manifest disease as type 2 diabetes. A total 54 obese subjects (54 men and 52 women ) and 45 lean subjects ( 25 men and 20 women) were enrolled to evaluate obesity by body mass index BMI, waist circumference, waist to hip ratio WHR and insulin resistance measured by HOMA-IR index. The results demonstrate that HOMA-IR is significantly higher in obese groups, males and females, compared with the control group of the same sexes and was positively correlated with the elevated values of body mass index, waist circumference, and waist to hip ratio in the tow sex.