Comparative Evaluation of Hematology and Biochemistry Before and After Administration of Nifedipine and Isoxsuprine in the Treatment of Preterm Labor.

Abstract

The safety profile of Nifedipine and Isoxsuprine on preterm diagnosed patients was assessed in this study. A total of 156 patients were included in the study, 78 patients data in each group was utilized for comparing the pre and post administration effects on blood biochemistry and hematology parameters. The dose of Isoxsuprine as an infusion of Inj. Isoxsuprine 40mg in 500ml Ringer lactate at 0.08mg/min, and nifedipine as an initial oral loading dose of 30 mg (10 sublingual and 20 mg oral) and maintenance dose oral dose of 20 mg at every 6 h did not affect the blood biochemistry and hematology of the preterm labor patients and were judged to be clinically non-significant in both the groups except a significant (p less than 0.05) increase in serum urea levels in Isoxsuprine treated patients.