Black Tea: A Possible Multitherapeutic Combinatorics Aiding Neuroprotection in Alzheimer’s Disease

Koushik Bhandari; Baishakhi De; Gargi Saha; Tridib K Goswami

doi:10.20425/ijts1419

Koushik Bhandari Advanced Technology Development Centre, Indian Institute of Technology, Kharagpur, West Bangal, India
Baishakhi De SSS Indira College of Pharmacy, Vishnupuri, Nanded, Maharashtra
Gargi Saha National Tea Research Foundation, Tea Board of India, West Bangal, Kolkata
Tridib K Goswami Department of Agriculture and Food Engineering, Indian Institute of Technology, Kharagpur, West Bangal, India

DOI: https://doi.org/10.20425/ijts1419

Keywords: Alzheimer's disease, Benzotropolone, Black tea, Neuroinflammation, Neuroprotective, Theaflavins.

Abstract

This article aims at reviewing the effectiveness of compounds in black tea in combating neuroinflammation in Alzheimer’s disease (AD). Detailed chemo profiling of black tea showed the presence of theaflavins, different catechins, and amino acids viz., L-theanine and methylxanthines. A literature search showed a multitude of pharmacological activities diversity of black tea. Structural and anti-inflammatory activity relationship studies showed the anti-inflammatory potentials of benzotropolone moiety containing compounds, flavonoids, flavones, phenolics and methylxanthines e.g. caffeine, theobromine, theophylline. Black tea is a good source of several multifunctional pharmacophores and thus can combat neuroinflammation in AD providing neuroprotection from multidimensional perspectives.