COMPARATIVE STUDY OF EFFICACY OF HYOSCINE BUTYLBROMIDE AND DROTAVERINE FOR AUGMENTATION OF LABOR

Abstract

Introduction: Prolonged labour contributes to increased perinatal and maternal morbidity.Various drugs have been tried to hasten the cervical dilatation. The ultimate aim of the obstetrician is to accomplish the delivery in the shortest possible time without compromising maternal and fetal safety. This study aims to compare the efficacy of Hyoscine Butyl Bromide with Drotaverine Hydrochloride for augmentation of labor. Material and Methods: This was a prospective study conducted on 120 women with term gestation; in active labor. The patients were chosen by simple randomization and were divided into 3 groups- A, B and C respectively of 40 patients each. Group A received intramuscular injection drotaverine hydrochloride one ampule (40 mg), group B received intramuscular injection hyoscine butylbromide (20 mg) and group C which was control group, received no drug. Results: The mean rate of cervical dilatation with buscopan was 2.23cm/hr while it was 2.03cm/hr and 2.08cm/hr in drotaverine group and control group respectively. Thus the drug delivery interval was less in buscopan group. Mean duration of active phase of first stage of labor was 156.13 minutes in buscopan group against 181.25 minutes in drotaverine group though buscopan was found to have less effect on duration of second stage of labor. Conclusion: Buscopan was found to be an effective and safe drug in shortening the duration of first stage of labor without any significant detrimental effects on the mother and newborn thereby minimizing maternal and fetal morbidity.